Paediatric gliomas: diagnosis, molecular biology and management

Pediatric Gliomas: Current Concepts on Diagnosis, Biology, and Clinical Management.

Gliomas are the most common CNS tumors in children and adolescents, and they show an extremely broad range of clinical behavior. The majority of pediatric gliomas present as benign, slow-growing lesions classified as grade I or II by the WHO classification of CNS tumors. These pediatric low-grade gliomas (LGGs) are fundamentally different from IDH-mutant LGGs occurring in adults, because they r...

Diagnosis and management of differentiated thyroid cancer using molecular biology.

OBJECTIVES/HYPOTHESIS To define molecular biology in clinical practice for diagnosis, surgical management, and prognostication of differentiated thyroid cancer. DATA SOURCES Ovid Medline 2006-2012 REVIEW METHODS Manuscripts with clinical correlates. RESULTS Papillary thyroid carcinomas harbor point mutations of the BRAF and RAS genes or RET/PTC rearrangements, all of which activate the mi...

Molecular biology of gliomas: present and future challenges

Malignant brain tumours are one of the most relevant causes of morbidity and mortality across a wide range of individuals. Malignant glioma is the most common intra axial tumor in the adult. Many researches on this theme brought advances in the knowledge of gliomas biology and pathogenesis and to the development of new agents for targeted molecular therapy. Recent studies focused on either tumo...

Gliomas Biology: Angiogenesis and Invasion

Diagnosis and Disease Management in CML Patients Using Conventional and Molecular Cytogenetics

Chronic Myeloid Leukemia (CML) is a hematopoietic malignancy characterized by the presence ofPhiladelphia (Ph1) chromosome that results from balanced reciprocal translocation between chromosomes9 and 22 leading in the formation of bcr/abl fusion gene. The present study was conducted to evaluate cytogenetic and molecular abnormalities in CML patients at presentation and during the co...